CRISPR-Cas9/Cas12a Systems for efficient genome editing and large genomic fragment deletions in Aspergillus niger
Guoliang Yuan, Shuang Hui Deng, Jeffrey J. Czajka, Ziyu Dai, Beth A. Hofstad, Joonhoon Kim, Kyle R. Pomraning
This paper compares CRISPR-Cas9 and Cas12a systems for genome editing and large fragment deletions in Aspergillus niger, showing Cas12a's higher efficiency with single gRNA and both systems achieving 100% efficiency with two gRNAs.
Frontiers in Bioengineering and Biotechnology · Oct 16, 2024Peer-reviewedMicrobiology