Galectin-3 drives neuroinflammatory amyloid remodeling by stabilizing intermediate Aβ species and altering lysosomal processing
Lluís Camprubí-Ferrer, Jesús Soldán-Hidalgo, Emil Axell, Marzia Dell’Eva, Marta García-Cruzado, Juan García‐Revilla, Yiyi Yang, Rosalía Fernández‐Calle, Logan Larlham, Bhanu Chouhan, Rocío Talaverón, Agnes Paulus, Lukas Danielson, Ángela Gómez-Arboledas, Oxana l. Klementieva, , Tomas Deierborg
This paper identifies Galectin-3 as a key regulator of amyloid-beta aggregation and microglial dysfunction in Alzheimer's disease, showing its role in neurotoxicity and potential as a therapeutic target.
bioRxiv · Mar 17, 2025 · PreprintNeuroscience