Oxana l. Klementieva

This paper investigates how environmental conditions influence the structural assembly and cytotoxic function of the Staphylococcus aureus virulence peptide PSM1, revealing condition-dependent polymorphic structures and their role in host-cell interactions.

The paper shows that neuronal age and ApoE4 genotype increase synaptic Aβ accumulation and alter its structural form in APPNL-F neurons.

This study shows that microplastics induce amyloid misfolding and metabolic disruption in Alzheimer's disease models at sub-lethal doses.

This paper introduces a mid-infrared photothermal mesoscope with millimeter-scale field of view and sub-micron resolution, enabling in vivo chemical imaging and Alzheimer's disease biomarker detection.

This paper identifies Galectin-3 as a key regulator of amyloid-beta aggregation and microglial dysfunction in Alzheimer's disease, showing its role in neurotoxicity and potential as a therapeutic target.

This paper describes a method to generate human parvalbumin interneurons from glial precursor cells using direct reprogramming and identifies a distinct transcriptional profile and reprogramming trajectory.

This paper demonstrates the use of O-PTIR for fast, non-destructive spatiotemporal chemical analysis of unprocessed biopsies, living brain tissue, and vertebrates.

The paper uses proteomic analysis of patient iPSC-derived brain cells and post-mortem hippocampal tissue to study early AD pathogenesis and prion-like spread.

The paper shows that ApoE4 increases Aβ42 levels in neurons and demonstrates intracellular intersection of ApoE with APP/Aβ in AD transgenic neurons.

This study shows that inflammatory bowel disease (IBD) leads to α-synuclein aggregation in the gut and brain, supporting Braak's hypothesis of Parkinson's disease origin in the enteric nervous system.