In silico engineered multitarget-directed ligands for the polypharmaceutical treatment of PTEN loss of function endometrial adenocarcinoma
Ritchie Delara, Vaidehi Mujumdar, Qi Zhang, Hailey L. Dryden, Erin Crane, Jubilee Brown, Wendel Naumann, Allison M. Puechl, David Foureau, Wei Sha, Jessica Legrand, Hsih‐Te Yang, Karl J. Dykema, Bharath Yada, Cody C. McHale, , Donald L. Durden
The paper designs in silico multitarget-directed ligands for treating PTEN loss of function endometrial adenocarcinoma by exploiting synthetic lethality between PTEN LOF and CDK9 inhibition.
bioRxiv · Aug 31, 2026 · PreprintCancer Biology