Rapid Peptide Mapping of Monoclonal Antibodies with Direct Infusion Mass Spectrometry
Austin Z. Salome, Marcel Morgenstern, Alexander S. Hebert, Craig D. Wenger, Pavel G. Sinitcyn, Benton J. Anderson, John S. Chlystek, Lia R. Serrano, Keaton L. Mertz, Ian J. Miller, Erik Miller-Galow, Malika P. Godamudunage, Michael Batt, Bhavin R. Patel, Gihoon Lee, , Joshua J. Coon
This paper introduces RaPiD-mAb-MS, a direct infusion mass spectrometry method for rapid peptide mapping of monoclonal antibodies, achieving 100-fold faster analysis with high sequence coverage and comparable results to conventional methods.
bioRxiv · May 16, 2026 · PreprintBiochemistry