Spatial tumor microenvironmental architecture of chemoradiotherapy-resistant residual esophageal squamous cell carcinoma
Sungwoo Bae, Jungyoon Ohn, Heesun Choi, H K Lee, Bhumsuk Kim, Chang Hyun Kang, Hak Jae Kim, Kwon Joong Na, Byoung Hyuck Kim
This study identifies spatial tumor microenvironment features of chemoradiotherapy-resistant residual esophageal squamous cell carcinoma using spatial transcriptomics and single-cell analysis, revealing SPP1-associated macrophage programs and microvascular rarefaction as key factors.
bioRxiv · Jun 4, 2026 · PreprintCancer Biology