Spatial tumor microenvironmental architecture of chemoradiotherapy-resistant residual esophageal squamous cell carcinoma
Sungwoo Bae, Jungyoon Ohn, Heesun Choi…·Byoung Hyuck Kim
This study identifies spatial tumor microenvironment features of chemoradiotherapy-resistant residual esophageal squamous cell carcinoma using spatial transcriptomics and single-cell analysis, revealing SPP1-associated macrophage programs and microvascular rarefaction as key factors.