Acute kidney injury disrupts cardiac remodeling via SerpinA3N
Gowda S. Pramod, Stanley Qu, Runze Ni, Nadezhda N. Zheleznova, Minghua Li, Nohely Hernandez, Lei Wang, Nathan Hall, Bi Zhao, Justin Gibbons, Nilam Sanjib Banerjee, Ganesh V. Halade, Lucian Lozonschi, Enyin Lai, Kristof Williams, Ruisheng Liu
This study shows that acute kidney injury increases SerpinA3N in the heart, which inhibits serine protease activity and promotes cardiac fibrosis and remodeling.
bioRxiv · Sep 19, 2025 · PreprintMolecular Biology