COPAL: An ensemble of protein-ligand co-folding models enriches preferred ligand predictions for the LuxR-family of quorum sensing receptors
Davi Nakajima An, Amy L. Schaefer, Szu-Min Chang, Bianxia Bai, Charlotte Mulligan, Yasuhiro Oda, Everett Peter Greenberg, Frank DiMaio
COPAL uses an ensemble of protein-ligand co-folding models to predict preferred AHL ligands for LuxR receptors, achieving higher accuracy than individual models.
bioRxiv · Sep 9, 2026 · PreprintBiochemistry