Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer
Tongchen He, Caleb Cheng, Yuanyuan Qiao, Hanbyul Cho, ELEANOR A. YOUNG, Rahul Mannan, Somnath Mahapatra, Stephanie J. Miner, Yang Zheng, Nam Hoon Kim, Victoria Zhixuan Zeng, Jasmine P. Wisniewski, Siyu Hou, Bailey Jackson, Xuhong Cao, , Arul M. Chinnaiyan
This paper develops an orally bioavailable PROTAC degrader of mSWI/SNF ATPases for prostate cancer and identifies resistance mechanisms through long-term treatment.
Proceedings of the National Academy of Sciences · Apr 1, 2024Peer-reviewedCancer Biology