BiochemistrybioRxivPreprint
Structural basis for inefficient G protein coupling by Frizzled receptors
Wessel A. C. Burger, Susovan Das, Hariprasad Venugopal…·Alisa Glukhova
The paper identifies detergent LMNG as stabilizing a weak FZD-G protein interface, revealing that FZDs inherently weakly couple to G proteins and preferentially signal through DVL.
DOI 10.64898/2026.11.03.763784