Kevin Huynh

The paper identifies detergent LMNG as stabilizing a weak FZD-G protein interface, revealing that FZDs inherently weakly couple to G proteins and preferentially signal through DVL.

This study shows that a high PUFA diet increases PL-PUFA content in immune cells and enhances their susceptibility to ferroptosis.

This paper develops a dual-omics workflow to map subcellular proteome and lipidome in mouse heart, revealing sex-dependent molecular differences and conserved subcellular lipid features.

This study identifies SHIP1 ligands with brain exposure and in vivo activity in Alzheimer's models, showing target engagement and reduced neuroinflammation.

This study shows that the mouse brain lipidome changes with diet and metabolic state, particularly highlighting the impact of high-fat diets on lipid remodeling in the hypothalamus and brainstem.

The paper identifies hallmark protein and lipid features of circulating extracellular vesicles in humans using multi-omics analysis and provides an open-source tool for further exploration.

This study examines how APOE genotypes affect brain metabolome changes with aging in mice, finding that APOE2 genotype is associated with better mitochondrial function and BCAA utilization.

This study shows that muscle-specific PolG dysfunction causes mitochondrial dysfunction and cachexia by activating the mtISR and altering the mitochondrial folate cycle.

This study identifies 667 genetic loci associated with lipid species and links 186 of them to coronary artery disease through integrative lipidomics and genomics.

The paper maps the developmental and intergenerational changes in the human circulatory lipidome and identifies lipid signatures associated with obesity risk in mothers and offspring.

The paper investigates sex and APOE ε4 genotype effects on metabolic alterations in Alzheimer’s disease using stratified analysis of serum metabolites.