Super-enhancer impairment is a link between MLL4 inactivated lung tumors and their vulnerability to glycolysis pathway inhibition
Hunain Alam, Ming Tang, Mayinuer Maitituoheti, Shilpa S. Dhar, Samir Amin, Bingnan Gu, Tsai-Yu Chen, Yu-His Lin, Jichao Chen, Florian Muller, Francesco J. DeMayo, Laura Baseler, Kunal Rai, Min Gyu Lee
The paper shows that MLL4 loss in lung cancer promotes glycolysis and that inhibiting glycolysis selectively targets MLL4-mutant lung tumors.
bioRxiv · Dec 28, 2018 · PreprintCancer Biology