Cancer BiologybioRxivPreprint
Super-enhancer impairment is a link between MLL4 inactivated lung tumors and their vulnerability to glycolysis pathway inhibition
Hunain Alam, Ming Tang, Mayinuer Maitituoheti…·Min Gyu Lee
The paper shows that MLL4 loss in lung cancer promotes glycolysis and that inhibiting glycolysis selectively targets MLL4-mutant lung tumors.