BiochemistryJournal of Biological ChemistryPeer-reviewed
E41K Mutation Activates Brutons Tyrosine Kinase by Stabilizing an Inositol Hexakisphosphate Dependent Invisible Dimer
Subhankar Chowdhury, Manas Pratim Chakraborty, Swarnendu Roy…·Rahul Das
The paper investigates the E41K mutation in BTK, showing it stabilizes an IP6-dependent PH-TH dimer, activating BTK independently of PIP3 binding.
3 citations