Foxd3 controls heterochromatin-mediated silencing of repeat elements in mouse embryonic stem cells and represses the 2-cell transcription program
Deepika Puri, Birgit Koschorz, Bettina Engist, Megumi Onishi‐Seebacher, Devon Patrick Ryan, Thomas Montavon
This study identifies FOXD3 as a regulator of repeat element transcription in mouse embryonic stem cells, showing it represses 2-cell state genes and repeat sequences by promoting heterochromatin formation.
bioRxiv · May 1, 2021 · PreprintDevelopmental Biology