GPLD1 Regulates the Shedding of IZUMO1R to Block Polyspermy in Porcine Oocyte
Boda Chen, Luting Shi, Fan Xia, Xingguo Chen, Jingyi Wang, Sitong Gao, Xiaoqian Zhou, Pengyun Ji, GuoShi Liu, Lu Zhang
The paper identifies GPLD1 as the enzyme mediating JUNO shedding in porcine oocytes, which is critical for preventing polyspermy and improving IVF outcomes.
bioRxiv · Apr 5, 2026 · PreprintDevelopmental Biology