Classification and phylogeny for the annotation of novel eukaryotic GNAT acetyltransferases
Bojan Krtenic, Adrian Drazic, Thomas Arnesen, Nathalie Reuter
This paper classifies eukaryotic GNAT acetyltransferases using sequence similarity networks and builds a phylogenetic tree, showing that NATs evolved multiple times on the GNAT scaffold and that small structural changes affect substrate specificity.
PLoS Computational Biology · Dec 23, 2020Peer-reviewedBioinformatics