Thomas Arnesen

Bidirectional control of a metabolic transition by the GID ubiquitin ligase

This study identifies Gid11 as a substrate receptor for the GID ubiquitin ligase in budding yeast, revealing its role in regulating metabolic transitions by targeting glycolytic factors during ethanol metabolism.

Naa80 is required for actin N-terminal acetylation and normal hearing in zebrafish

This study shows that zebrafish Naa80 acetylates actins and is essential for normal hearing, but not for muscle development or viability.

Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice

The paper evaluates maternal effect lethality and genetic background effects in Naa10 knockout mice, finding no replication of maternal effect lethality but some embryonic lethality in specific genetic backgrounds.

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

The paper shows that N-terminal acetylation by NatC protects proteins from degradation, enhancing longevity and motility, and that UBR4-KCMF1 targets unacetylated N-terminal Met followed by hydrophobic residues.

Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway

The paper identifies Naa12 as a compensatory N-terminal acetyltransferase that rescues Naa10 deficiency in mice, revealing its role in amino-terminal acetylation.

Classification and phylogeny for the annotation of novel eukaryotic GNAT acetyltransferases

This paper classifies eukaryotic GNAT acetyltransferases using sequence similarity networks and builds a phylogenetic tree, showing that NATs evolved multiple times on the GNAT scaffold and that small structural changes affect substrate specificity.

Dynamics-function relationship of N-terminal acetyltransferases: the β6β7 loop modulates substrate accessibility to the catalytic site