Adrian Drazic

A global genetic interaction map of a human cell reveals conserved principles of genetic networks

The paper constructs a genome-scale genetic interaction network from 4 million double mutants in HAP1 cells, revealing conserved genetic network principles across species and uncovering novel gene functions and cancer dependencies.

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

The paper shows that N-terminal acetylation by NatC protects proteins from degradation, enhancing longevity and motility, and that UBR4-KCMF1 targets unacetylated N-terminal Met followed by hydrophobic residues.

Classification and phylogeny for the annotation of novel eukaryotic GNAT acetyltransferases

This paper classifies eukaryotic GNAT acetyltransferases using sequence similarity networks and builds a phylogenetic tree, showing that NATs evolved multiple times on the GNAT scaffold and that small structural changes affect substrate specificity.