A2AR-mediated inhibition of B cell maturation: a novel mechanism of immune suppression in cancer
Paola Tieppo, Hussein Shehade, Chiara Martinoli, Marjorie Mercier, David Carbonez, Nicolas Rosewick, Sophie Jung, Anais Vezzu, Boris Pirlot, Noémie Wald, Stephanie Ma, Lucas Martins Chaible, Reece G. Marillier, Francesco Strozzi, João Marchante, , Maura Maria Rossetti
This study shows that A2AR inhibition enhances B cell maturation into antibody-secreting cells in the tumor microenvironment, reversing immune suppression.
bioRxiv · Aug 13, 2025 · PreprintImmunology