Mice hypomorphic for Pitx3 define a minimal dopamine neuron population sufficient for entraining behavior and metabolism to scheduled feeding
Lori L. Scarpa, Brad Wanken, Marten P. Smidt, Ralph E. Mistlberger, Andrew D. Steele
The paper confirms that Pitx3ak mice do not entrain behavioral and metabolic rhythms to light-dark cycles but can entrain to feeding schedules, suggesting a minimal dopamine neuron population is sufficient for food entrainment.
bioRxiv · Oct 23, 2020 · PreprintNeuroscience