Andrew D. Steele

This study shows that deleting tyrosine hydroxylase in Ntsr1 neurons reduces diet-induced weight gain without increasing energy expenditure or activity.

This study shows that social housing suppresses food anticipatory activity and thermoregulation in mice, indicating social context influences circadian rhythms.

The paper develops a knock-in Ntsr1-Flp mouse line for intersectional targeting of midbrain dopamine circuits and demonstrates its utility in distinguishing dopaminergic and non-dopaminergic neurons.

The paper identifies a specific dopamine neuron population in mice required for anticipatory locomotion during food anticipation, showing genetic dissociation of behavioral components.

The paper shows that proposed GPCR markers for adult dopamine neurons, like Nmur1 and Cckar, lack functional expression and challenge existing atlas assignments.

This study demonstrates that systemic AAV delivery enables widespread calcium indicator expression in marmosets, allowing functional optical imaging of visual area MT at multiple scales.

This study engineers AAVs targeting human carbonic anhydrase IV to enhance brain gene delivery, finding that optimized variants achieve 100-fold greater transduction than AAV9.

This study shows that mice lacking dopamine production in neurotensin receptor 1 neurons resist obesity on a high fat diet by not increasing daytime eating.

This study investigates the role of D1R signaling in food anticipatory activity (FAA) in mice, finding that while D1R promotes FAA, other dopamine receptors also contribute.

The paper confirms that Pitx3ak mice do not entrain behavioral and metabolic rhythms to light-dark cycles but can entrain to feeding schedules, suggesting a minimal dopamine neuron population is sufficient for food entrainment.