Cross-ancestry and phenome-wide associations of cancer-specific polygenic risk scores
Louise L. Wang, Heena Desai, Craig Carl Teerlink, Oliver Clark, Kathryn M. Pridgen, Jennifer S. Lee, Kyong‐Mi Chang, Rachel L. Kember, Marijana Vujković, Julie Ann Lynch, Kara N. Maxwell, On Behalf of the VA Million Veteran Program, Sumitra Muralidhar, Jennifer Moser, Jennifer E. Deen, , Henry R. Kranzler
This study evaluates cancer-specific polygenic risk scores (PRS) across diverse ancestries and finds they predict corresponding cancers with varying effectiveness and limited pleiotropy.
JCO Precision Oncology · Sep 1, 2026Peer-reviewedGenetic & Genomic Medicine