Adriana M. Hung

Cross-ancestry and phenome-wide associations of cancer-specific polygenic risk scores

This study evaluates cancer-specific polygenic risk scores (PRS) across diverse ancestries and finds they predict corresponding cancers with varying effectiveness and limited pleiotropy.

Genome sequencing of 35,024 predominantly African ancestry persons addresses gaps in genomics and healthcare

This study sequenced 35,024 individuals with predominantly African ancestry to address gaps in genomics and healthcare, finding under-documented disease variants and novel associations with drug adverse events and glycemic control.

Integrative Proteome- and Phenome-Wide Assessment Uncovers Causal Protein Drivers and Drug Targets for Heterogeneous Kidney Diseases

The paper identifies causal protein drivers and drug targets for heterogeneous kidney diseases using proteome-wide Mendelian randomization and EHR data.

Genetics of cardiovascular outcomes in individuals with chronic kidney disease: the Chronic Renal Insufficiency Cohort (CRIC) study

The paper performs GWAS on cardiovascular outcomes in CKD patients, identifying stroke-associated SNVs but not replicating CHD findings, and finding genetic correlations with published GWAS.

Diversity and Scale: Genetic Architecture of 2,068 Traits in the VA Million Veteran Program

Population-stratified GWAS of 2,068 traits in 635,969 Million Veteran Program participants, 29% genetically non-European, yields 98,485 associations and 57,601 fine-mapped signals with largely shared cross-population architecture.

Association between APOL1 risk variants and the occurrence of sepsis in Black patients hospitalized with infections: a retrospective cohort study

This study investigates the association between APOL1 risk variants and sepsis occurrence in Black patients with infections, finding that the increased risk is largely due to pre-existing severe renal disease.

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program

This study identifies genetic variants associated with severe COVID-19 and finds shared genetic architecture with complex diseases using EHR data from the Million Veteran Program.

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

The paper maps genetic variants to cell types in the kidney to identify disease mechanisms and drug targets.

Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals

This study identifies 424 new loci associated with kidney function using GWAS data from over 1.2 million individuals and prioritizes 34 genes for further functional investigation.