Henry R. Kranzler

Cross-ancestry and phenome-wide associations of cancer-specific polygenic risk scores

This study evaluates cancer-specific polygenic risk scores (PRS) across diverse ancestries and finds they predict corresponding cancers with varying effectiveness and limited pleiotropy.

Genomic Architecture of Migraine: A Multi ancestry GWAS Meta analysis of 2.5 Million Participants

This study conducts a multi-ancestry GWAS meta-analysis of 2.5 million participants to identify genetic variants associated with migraine and link them to biological pathways and therapeutic targets.

Shared Genetic Architecture and Neurobiological Pathways of Problematic Alcohol Use and Anxiety Disorders

This study identifies shared genetic and neurobiological pathways between problematic alcohol use and anxiety disorders using genomic analyses.

Multi-ancestry genome-wide association study and meta-analysis of stimulant use disorder reveals biology and relationships to other psychiatric disorders

This paper conducts a multi-ancestry GWAS of stimulant use disorder, identifies 19 genome-wide significant loci, and finds genetic correlations with other psychiatric and substance use disorders.

Suicidality phenotypes reflect both shared and distinct genetic factors

This study identifies shared and distinct genetic factors underlying suicidality phenotypes using GWAS and structural equation modelling.

Genetic and Proteomic Investigation of the Smoking-Parkinson Disease Association

This study investigates the causal relationship between smoking and Parkinson's disease using genetic and proteomic data, identifying shared biological pathways and potential therapeutic targets.

Multivariate, Multi-omic Analysis in 799,429 Individuals Identifies 134 Loci Associated with Somatoform Traits

Pathways from Polygenic Risk to Suicidality: Effects of Alcohol Use Disorder and Childhood Adversity

The paper examines how polygenic risk for suicide attempts interacts with alcohol use disorder and childhood adversity to influence suicide attempt risk.

Phenome-wide analysis of genetically imputed neuroimaging phenotypes reveals associations with psychiatric traits in a multi-ancestry cohort

The paper uses genetically imputed brain imaging phenotypes to find associations with psychiatric traits in a multi-ancestry cohort.

Multi-ancestry Genome-wide Association Study of Inpatient Opioid Dosing Following Knee or Hip Arthroplasty

This study investigates genetic predictors of inpatient opioid exposure after knee or hip surgery using EHR and genotype data from 27,896 individuals across three ancestries, finding no genome-wide significant loci.

Disaggregating the Genetic Overlap Between Educational Attainment and Substance Use Phenotypes

The paper investigates the genetic overlap between educational attainment and substance use traits, finding distinct genetic patterns for cognitive and non-cognitive components of education.

Etiological basis for chronic pain genetic variation in brain and dorsal root ganglia cell types

This paper identifies cell-type-specific genetic variants associated with chronic pain using GWAS and scRNA-seq data from brain and dorsal root ganglia tissues.

Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality

This study identifies 1,257 genetic variants associated with human personality traits using large-scale GWAS and finds widespread genetic correlations with behaviors and life outcomes.

Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations

The paper investigates genetic and neural overlaps between alcohol use disorder and BMI, finding polygenic overlap despite minimal genetic correlation and identifying shared brain regions involved in executive function and reward.

Gene discovery and pleiotropic architecture of Chronic Pain in a Genome-wide Association Study of >1.2 million Individuals

This study identifies 343 genetic loci for chronic pain in 1.2 million individuals, revealing pleiotropy with psychiatric disorders and brain structures.

Integrating HiTOP and RDoC Frameworks Part II: Shared and Distinct Biological Mechanisms of Externalizing and Internalizing Psychopathology

The paper integrates HiTOP and RDoC frameworks to identify shared and distinct biological mechanisms of externalizing and internalizing psychopathology using multi-omics approaches.

Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.

This study performs a multi-ancestral GWAS of DSM-defined nicotine dependence, finding genetic correlations with other substance use disorders and health traits, and identifying a strong general addiction liability factor.

Integrating HiTOP and RDoC Frameworks Part I: Genetic Architecture of Externalizing and Internalizing Psychopathology

The paper uses genomic structural equation modeling to identify the genetic architecture of externalizing and internalizing psychopathology, finding a moderate genetic correlation and shared causal variants.

Divergent gene expression in alcohol and opioid usedisorders results in consistent alterations in functional networks in the Dorsolateral Prefrontal Cortex

This study identifies divergent gene expression in AUD and OUD but finds shared biological pathways in the dorsolateral prefrontal cortex, suggesting potential therapeutic targets.

Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter.

The paper identifies SLC45A4 as a pain-related gene encoding a neuronal polyamine transporter through GWAS and functional studies.

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology.

This study conducts a genome-wide association analysis of the Big Five personality traits, identifying novel genetic loci and associations with psychiatric traits.

A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens

The paper analyzes single-nucleus RNA sequencing data from rat nucleus accumbens medium spiny neurons to identify transcriptomic subtypes and their potential roles in substance use disorders.

Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and medical traits

The paper uses polygenic scores to analyze pleiotropy between psychiatric, medical, and substance use disorders in a deeply phenotyped sample, finding extensive genetic overlap with substance use phenotypes.

Shared and unique chromatin accessibility and 3D functional interactions of substance use disorder loci implicate cell types beyond the brain

This paper identifies shared and unique chromatin accessibility and 3D interactions of SUD loci, implicating non-neural cell types like pancreatic β-cells and showing a causal link between T2D and AUD.

Diversity and Scale: Genetic Architecture of 2,068 Traits in the VA Million Veteran Program

Population-stratified GWAS of 2,068 traits in 635,969 Million Veteran Program participants, 29% genetically non-European, yields 98,485 associations and 57,601 fine-mapped signals with largely shared cross-population architecture.

Combining Transdiagnostic and Disorder-Level GWAS Enhances Precision of Psychiatric Genetic Risk Profiles in a Multi-Ancestry Sample

This paper combines transdiagnostic and disorder-level GWAS to enhance genetic risk profiles for psychiatric disorders in multi-ancestry samples, identifying novel SNPs and shared genetic variance.

Multi-ancestry Whole-exome Sequencing Study of Alcohol Use Disorder in Two Cohorts

This study conducts a multi-ancestry whole-exome sequencing analysis of alcohol use disorder in two cohorts, identifying genetic variants associated with AUD.

Genetic underpinnings of the transition from alcohol consumption to alcohol use disorder: shared and unique genetic architectures in a cross-ancestry sample

This study identifies genetic loci associated with alcohol use disorder and consumption, finding distinct genetic architectures and variants with direct effects on AUD.

Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program

This study uses multi-trait analysis to identify novel genetic loci for smoking behaviors by leveraging alcohol use disorder GWAS data from the Million Veteran Program.

Multi-ancestry meta-analysis of tobacco use disorder based on electronic health record data prioritizes novel candidate risk genes and reveals associations with numerous health outcomes

This study performs a multi-ancestry meta-analysis of tobacco use disorder using electronic health records, identifying 88 risk loci and 461 potential risk genes, and linking TUD to various health outcomes.