Author

Louise L. Wang

University of PennsylvaniaORCID 0000-0002-9261-8371Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Heena DesaiiD· 2 shared Kara N. MaxwelliD· 2 shared Rachel L. KemberiD· 2 shared Abigail G. DoucetteiD· 1 shared Adam J. Mansfield· 1 shared Adriana M. HungiD· 1 shared Alan Shuldiner· 1 shared Alexander Lopez· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Heena DesaiORCID

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2 papers

Recent·Most cited

Cross-ancestry and phenome-wide associations of cancer-specific polygenic risk scores

Louise L. Wang, Heena Desai, Craig Carl Teerlink, Oliver Clark, Kathryn M. Pridgen, Jennifer S. Lee, Kyong‐Mi Chang, Rachel L. Kember, Marijana Vujković, Julie Ann Lynch, Kara N. Maxwell, On Behalf of the VA Million Veteran Program, Sumitra Muralidhar, Jennifer Moser, Jennifer E. Deen, , Henry R. Kranzler

This study evaluates cancer-specific polygenic risk scores (PRS) across diverse ancestries and finds they predict corresponding cancers with varying effectiveness and limited pleiotropy.

JCO Precision Oncology · Sep 1, 2026Peer-reviewedGenetic & Genomic Medicine

Performance of polygenic risk scores for cancer prediction in a racially diverse academic biobank

Louise L. Wang, Heena Desai, Shefali S. Verma, Anh N. Le, Ryan M. Hausler, Anurag Verma, Renae Judy, Abigail G. Doucette, Peter Edward Gabriel, Goncalo Abecasis, Xiaodong Bai, Suganthi Balasubramanian, Aris Baras, Andrew Blumenfeld, Boris Boutkov, , Kara N. Maxwell

This study evaluates polygenic risk scores (PRS) for cancer prediction in a racially diverse biobank, finding moderate improvements in discriminatory accuracy for European ancestry but limited gains for African ancestry.

Genetics in Medicine · Nov 30, 2021Peer-reviewedGenetic & Genomic Medicine