Chalcone isomerase-like impedes the lactone shunt and enhances flux partitioning in a bifurcated pathway towards isoflavonoid biosynthesis
Lee Marie Raytek, Brandon Corey Saltzman, Meha Sharma, Soon Goo Lee, Mehran Dastmalchi
This study shows that Chalcone isomerase-like proteins reduce lactone by-product formation and increase target compound titers in engineered yeast for isoflavonoid biosynthesis.
Biochemical Engineering Journal · Jul 3, 2025Peer-reviewedSynthetic Biology