Transcriptomic Signature and PROTAC Strategy Revealed Histone Lysine Demethylase as a Target of Anticancer Activity of Deferiprone.
Alexis Johnston, Jeremiah Olorunjuwon Olugbami, Dipak T. Walunj, Arvind Bangaru, Bocheng Wu, Ryan Kern, Ruiqiao Yang, Travis J. Nelson, Brandon J. Clarke, Janani Murugan, Nathaniel A. Hathaway, Yuhong Fan, Adegboyega K. Oyelere
This study identifies KDM inhibition as a key anticancer mechanism of DFP and demonstrates PROTACs as a strategy to enhance its therapeutic potential.
ACS Omega · Apr 28, 2026Peer-reviewedCancer Biology