Author

Nathaniel A. Hathaway

University of North Carolina at Chapel HillORCID 0000-0002-9807-0167Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adegboyega K. OyelereiD· 2 shared Alexis JohnstoniD· 2 shared Bocheng WuiD· 2 shared Dipak T. WalunjiD· 2 shared Jeremiah Olorunjuwon OlugbamiiD· 2 shared Ryan Kern· 2 shared Travis J. NelsoniD· 2 shared Arvind Bangaru· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Adegboyega K. OyelereORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Dual-acting Estrogen Receptor Modulator-Histone Lysine Demethylase Inhibitors

Dipak T. Walunj, Jeremiah Olorunjuwon Olugbami, Bocheng Wu, Ryan Kern, Alexis Johnston, Sonia Batan, Jabunnesa Khanom, Femi A. Egbeleke, Travis J. Nelson, Verjine Khodaverdian, Veronica Ventura, Nathaniel A. Hathaway, Muthusamy Thangaraju, Adegboyega K. Oyelere

This paper develops dual-acting inhibitors combining estrogen receptor ligands with KDM inhibitors, showing potent anti-proliferative effects against both ER+ and ER- breast cancer cells in xenograft models.

bioRxiv · May 29, 2026 · PreprintCancer Biology

Transcriptomic Signature and PROTAC Strategy Revealed Histone Lysine Demethylase as a Target of Anticancer Activity of Deferiprone.

Alexis Johnston, Jeremiah Olorunjuwon Olugbami, Dipak T. Walunj, Arvind Bangaru, Bocheng Wu, Ryan Kern, Ruiqiao Yang, Travis J. Nelson, Brandon J. Clarke, Janani Murugan, Nathaniel A. Hathaway, Yuhong Fan, Adegboyega K. Oyelere

This study identifies KDM inhibition as a key anticancer mechanism of DFP and demonstrates PROTACs as a strategy to enhance its therapeutic potential.

ACS Omega · Apr 28, 2026Peer-reviewedCancer Biology

Nucleosome turnover is sufficient to establish varied histone methylation states

Emma J. Chory, Joseph P. Calarco, Nathaniel A. Hathaway, Oliver Bell, Dana S. Neel, Gerald R. Crabtree

This study shows that nucleosome turnover can establish varied H3K79 methylation states without active demethylation.

bioRxiv · Jan 31, 2018 · PreprintMolecular Biology