An Integrating Sphere Based Method for Quantifying RNA Encapsulation Efficiency in Lipid Nanoparticles without Lysis
Aida López Espinar, Eric C. Le Ru, Kirsty Smith, Brendan L. Darby
The paper introduces a lysis-free method to quantify RNA encapsulation efficiency in lipid nanoparticles using Scatter-Free Absorption Spectroscopy, achieving high accuracy comparable to traditional methods.
bioRxiv · Jun 1, 2026 · PreprintMolecular Biology