Molecular BiologybioRxivPreprint
An Integrating Sphere Based Method for Quantifying RNA Encapsulation Efficiency in Lipid Nanoparticles without Lysis
Aida López Espinar, Eric C. Le Ru, Kirsty Smith, Brendan L. Darby
The paper introduces a lysis-free method to quantify RNA encapsulation efficiency in lipid nanoparticles using Scatter-Free Absorption Spectroscopy, achieving high accuracy comparable to traditional methods.
DOI 10.64898/2026.05.29.728751