Adrenal rather than central dysfunction limits HPA axis recovery after chronic glucocorticoid treatment in male mice
Lindsey S. Gaston, Brenna Jorgensen, Hannah Friedman, Marc Samuel Sherman, Joseph A. Majzoub
This study identifies the adrenal as the primary site limiting HPA axis recovery after chronic glucocorticoid treatment in male mice, showing adrenocortical cell loss and steroidogenesis defects.
Endocrinology · Jul 8, 2026Peer-reviewedPhysiology