A deep learning approach for the discovery of tumor-targeting small organic ligands from DNA-Encoded Chemical Libraries
Wen Torng, Ilaria Biancofiore, Sebastian Oehler, Jin Hua Xu, Jessica A. Xu, Ian Watson, Brenno Masina, Luca Prati, Nicholas Favalli, Gabriele Bassi, Dario Neri, Samuele Cazzamalli, Jianwen A. Feng
The paper uses deep learning to identify tumor-targeting ligands from DNA-encoded chemical libraries against CAIX, finding 70% of novel hits show submicromolar activity.
ACS Omega · Jul 6, 2023Peer-reviewedBioinformatics