Synthetic and genomic regulatory elements reveal aspects of cis-regulatory grammar in Mouse Embryonic Stem Cells
Dana King, Clarice KY Hong, James L. Shepherdson, David M. Granas, Brett B. Maricque, Barak A. Cohen
The paper uses MPRA libraries to analyze cis-regulatory grammar in mouse ESCs, finding that synthetic and genomic elements share binding site quality as a key factor, but genomic activity is better explained by binding site affinity and spacing.
eLife · Feb 11, 2020Peer-reviewedGenomics