Dana King

The SRG RAT supports human cell xenotransplantation through enhanced tumor microenvironment interactions

This study shows that SRG rats support better human tumor growth and microenvironment interactions compared to NSG mice, despite similar immunodeficiency levels.

Sleep-dependent engram reactivation during hippocampal memory consolidation is associated with subregion-specific biosynthetic changes

This study shows that sleep-dependent reactivation of engram neurons in the hippocampal dentate gyrus is subregion-specific and linked to changes in biosynthetic processes during memory consolidation.

CLIP-Seq and massively parallel functional analysis of the CELF6 RNA binding protein reveals a role in destabilizing synaptic gene mRNAs through interaction with 3’UTR elements in vivo

This study identifies CELF6 mRNA targets using CLIP-Seq and shows CELF6 represses synaptic gene translation by reducing RNA abundance through UGU-rich motifs, extending its known role beyond splicing.

Synthetic and genomic regulatory elements reveal aspects of cis-regulatory grammar in Mouse Embryonic Stem Cells

The paper uses MPRA libraries to analyze cis-regulatory grammar in mouse ESCs, finding that synthetic and genomic elements share binding site quality as a key factor, but genomic activity is better explained by binding site affinity and spacing.