Human polymerase theta helicase positions DNA microhomologies for double-strand break repair
Christopher J. Zerio, Yonghong Bai, Brian A Sosa, Timothy J. Guzi, Gabriel C. Lander
This paper reveals the molecular mechanism of polymerase theta helicase in positioning DNA microhomologies for error-prone double-strand break repair using cryo-electron microscopy structures.
bioRxiv · Apr 26, 2024 · PreprintMolecular Biology