Conserved synaptic modifications by humanized tau through diverse isoform- and mutation-specific intracellular interactions
Emily Nickerson, Justice Pomeroy-Tuck, Samia Pratt, Carly Rodriguez, Tengteng Zhao, Tim Stodola, Brian Hoffman, Rick Maser, Erik Bloss
The paper investigates how different humanized tau isoforms and mutations affect synaptic connectivity and interact with mitochondrial proteins in cortical neurons.
bioRxiv · Nov 4, 2026 · PreprintNeuroscience