Functional High Throughput Drug Screening Reveals Cyproheptadine as a Novel Treatment for LMNA -related Cardiomyopathy
Hananeh Fonoudi, Ali Negahi Shirazi, Hui–Hsuan Kuo, Carlos G. Vanoye, Xiaozhi Gao, Susan Doody, Mariam Jouni, Brian Lenny, Achal Neupane, Janavi Kotamarthi, Yadav Sapkota, Jane E. Wilcox, Alfred L. George, Paul W. Burridge
This paper uses patient-derived hiPSC-CMs to identify cyproheptadine as a therapeutic for LMNA-related DCM by revealing shared and variant-specific disease mechanisms.
bioRxiv · Jun 16, 2026 · PreprintCell Biology