Proximity-Informed Graph Learning Defines Spatial Protein Communities for Tumor-Associated Proximity Antigen Discovery
Cody Scandore, Clare F. Malone, Christopher K. May, Anna K. de Regt, Jeff Guernsey, Hayley Ma, Noah Dephoure, Ben Setter, Rebecca A. Howell, Kendall R. Johnson, Carol L. Farr, Sophia Romero, Lydia Vignale, Tali Vittum, Emma Dawson, , Olugbeminiyi Fadeyi
The paper develops a proximity mapping workflow to identify tumor-associated antigens by analyzing spatial protein communities and validates a TAA-TAPA pair that enhances tumor cell killing.
bioRxiv · Feb 16, 2026 · PreprintCancer Biology