Noah Dephoure

The paper develops a proximity mapping workflow to identify tumor-associated antigens by analyzing spatial protein communities and validates a TAA-TAPA pair that enhances tumor cell killing.

This study shows that invasive cancer cells use lysosome-mediated nutrient scavenging during EMT, bypassing plasma membrane transport, and that this process is regulated by c-MYC downregulation.

This study identifies upstream kinases and spatial mechanisms involved in TBK1 activation using a specific inhibitor, revealing crosstalk with IKKβ and IKKε.

This study investigates the role of KLF4 in chromatin reorganization and 3D enhancer rewiring during reprogramming of mouse embryonic fibroblasts to pluripotent stem cells.

The paper trains a random forest classifier, ForestMHC, to predict MHC-I peptide presentation using a million human peptides, outperforming existing tools on test sets and mass spectrometry data.