An osmolarity dependent mechanism partially ameliorates retinal cysts and rescues cone function in a mouse model of X-linked Retinoschisis.
Ella J. Gehrke, Jacob M. Thompson, Emily Kalmanek, Sarah T. Stanley, Joseph G. Laird, Sajag Bhattarai, Brianna Lobeck, Sara K. Mayer, Angela Mahoney, Salma Hassan, Ying Hsu, Arlene V. Drack
This study shows that a hypertonic buffer reduces retinal cysts and improves cone function in Rs1-KO mice, suggesting an osmolarity-dependent therapeutic effect.
Frontiers in Medicine · Oct 15, 2024Peer-reviewedGenetics