Ying Hsu

An osmolarity dependent mechanism partially ameliorates retinal cysts and rescues cone function in a mouse model of X-linked Retinoschisis.

This study shows that a hypertonic buffer reduces retinal cysts and improves cone function in Rs1-KO mice, suggesting an osmolarity-dependent therapeutic effect.

Delivering large genes using adeno-associated virus and the CRE-lox DNA recombination system

This paper describes a method to deliver large genes using AAV vectors and the CRE-lox system, enabling efficient reconstitution of therapeutic genes beyond AAV packaging limits.

Knockout of Bbs10 results in lack of cone electrical function and progressive retinal degeneration of rods and cones

This study develops a BBS10 knockout mouse model to investigate retinal degeneration, finding progressive loss of cone function and thinning of the outer nuclear layer.