A telomere-to-telomere map of somatic mutation burden and functional impact in cancer
Min-Hwan Sohn, Danilo Dubocanin, Mitchell Robert Vollger, Young-Jun Kwon, Anna Minkina, Katherine M. Munson, Samuel F. M. Hart, Jane E. Ranchalis, Nancy L. Parmalee, Adriana Estela Sedeño-Cortés, Jeffrey Ou, Natalie Y.T. Au, Stephanie C. Bohaczuk, Brianne Carroll, Christian D. Frazar, , Andrew B. Stergachis
The paper maps somatic mutation burden and functional impact across the cancer genome using telomere-to-telomere sequencing, revealing novel mutation hotspots and regulatory rewiring mechanisms.
bioRxiv · Oct 10, 2025 · PreprintGenomics