Divalent HIV-1 gp120 Immunogen Exhibits Selective Avidity for Broadly Neutralizing Antibody VRC01 Precursors
Ryan Bailey, Kalista Kahoekapu, Albert To, Ludwig I. Mayerlen, Helmut Kae, Gabriel Manninen, Brien K. Haun, John M. Berestecky, Cecilia Shikuma, Axel T. Lehrer, Iain MacPherson
This paper designs a rigid divalent immunogen that selectively binds VRC01-class antibodies with higher avidity than non-target antibodies, supporting its use in vaccine development.
Vaccines · Jan 3, 2026Peer-reviewedImmunology