Advancing Tolerogenic Immunotherapy: A Multi-Epitope Vaccine Design Targeting the CYP2D6 Autoantigen in Autoimmune Hepatitis Through Immuno-Informatics
Harish Babu Kolla, Anuj Kumar, Roopa Hebbandi Nanjunadappa, Briley Hillyard, Mansi Dutt, Deepak Chauhan, Jean Marshal, David Kelvin, Channakeshava Sokke Umeshappa
This paper designs a multi-epitope tolerogenic vaccine targeting CYP2D6 for autoimmune hepatitis using immuno-informatics, showing it induces IL-10 and programs dendritic cells toward a tolerogenic state.
bioRxiv · Apr 17, 2024 · PreprintImmunology