Rapid precision targeting of nanoparticles to lung via caveolae pumping system in endothelium
Tapas Ranjan Nayak, Adrián Chrastina, Jose Valencia, Oscar Cordova-Robles, Robert Yedidsion, Tim Buss, Brittany Cederstrom, Jim Koziol, Michael D. Levin, Bogdan Z. Olenyuk, Jan E. Schnitzer
This study demonstrates that the caveolae pumping system in lung endothelial cells can rapidly and specifically deliver nanoparticles to the lungs, outperforming passive delivery and RES scavenging.
Nature Nanotechnology · Oct 8, 2024Peer-reviewedBioengineering