Behavioral changes preceded by subthalamic nucleus alterations in a progressive macaque model of Parkinson's disease.
Mathilde Bertrand, Jessy Hugues Dit Ciles, Stéphan Chabardès, Nicolas De Leiris, Bruno Baudin, Julien Bastin, Brigitte Piallat
This study shows that STN dysfunction precedes motor symptoms in a macaque PD model and suggests targeted stimulation strategies for both motor and non-motor symptoms.
bioRxiv · Jan 22, 2024 · PreprintNeuroscience