Pathway-based Rare Variant Burden Analysis Identifies a Role for the Complement System in an Extreme Phenotype of Sepsis with Coagulopathy
Pavan K. Bendapudi, Sumaiya Nazeen, Justine H. Ryu, Onuralp Söylemez, Betty Rouaisnel, Meaghan E. Colling, Bryce E. Pasko, Alissa K. Robbins, Michael Bouzinier, Lindsay Tomczak, Lindsay Collier, Sanjay Ram, Ágnes Tóth-Petróczy, Joel B. Krier, Elizabeth L. Fieg, , Julie-Aurore Losman
The paper identifies rare variants in the complement system associated with severe sepsis with coagulopathy using pathway-based analysis of whole exome sequencing data.
medRxiv · Feb 24, 2022 · PreprintGenetic & Genomic Medicine