Sanjay Ram

This paper demonstrates that a hexameric C4BP IgG Fc fusion protein significantly enhances complement-dependent bactericidal activity and reduces gonococcal vaginal colonization in mice.

This study shows C4BP inhibits Neisseria gonorrhoeae's interaction with neutrophil CEACAMs, reducing phagocytic killing by blocking Opa-CEACAM binding.

This study determines the structural basis for mAb 2C7 recognition of a gonococcal LOS epitope, identifying a minimal tetrasaccharide that retains key binding determinants for vaccine and therapeutic design.

This study characterizes the sialome of the human retina and identifies alterations in age-related macular degeneration (AMD) that may impact complement factor H binding.

The paper identifies rare variants in the complement system associated with severe sepsis with coagulopathy using pathway-based analysis of whole exome sequencing data.